Thomas Ostwald and David MacLennan were characterizing proteins that bind to calcium in the sarcoplasmic reticulum — a specialized type of endoplasmic reticulum found in muscle cells.

The story begins in the endoplasmic reticulum—the cellular ... wrinkled mess of fabric, but when folding fails among the approximately 7,000 proteins with an origami-like complexity that ...

Here I discuss recent advances in the study of endoplasmic reticulum stress as one mechanism ... using new genetic or chemical models, to modify ER folding capacity upstream of the apoptotic ...

Our research focuses on studies on the molecular structure and mechanism of proteins, recently mostly on the endoplasmic reticulum proteins involved in cellular stress signalling, including in ...