After exposure to trans-retinoic acid, these cells can develop into two distinct forms of extra-embryonic endoderm. To date, differential library screening has been the best tool available to ...

Further cell divisions lead to the formation of the primitive endoderm, which forms a blastocyst. This structure implants around one week after fertilization. As development continues, the epiblast ...

We are interested in how cells become specialized, and how they collaborate at the population level to collectively build organs. Our focus is on the endoderm, the progenitor tissue that gives rise to ...

In a new study published in eLife, the researchers focused on the outermost visceral endoderm cells of mouse embryos. By ...

To treat his impaired islet cell function, the research team generated functional islet-like clusters, called “E-islets,” from the patient’s own endoderm stem cells derived from blood cells.