DUSP6 regulates the MAPK pathway, specifically extracellular signal-regulated kinases 1 and 2 (ERK1/2). Here’s how it works under normal circumstances: In response to signals from the MAPK ...

To assess whether the aberrant activation of ERK1/2 and JNK pathways is involved in the reduced viability of α-synucleinopathy neurons, the research team treated α-synucleinopathy neurons with ...

DUSP6 is a type of protein called a phosphatase that acts like a "switch-off" mechanism for specific signalling pathways inside cells. Its main function is to control the ERK1/2 MAPK pathway ...