The researchers designed an efficient approach for fabricating engineered Pts-based nano-aircraft carriers with graded drug delivery and ECM degradation for precise cancer chemoimmunotherapy.

"In a normal tissue, the spacing on the ECM is around 50–70 nanometers (nm), but in the tumor microenvironment, severe choking occurs due to excessive ECM secretion, which may reduce the binding ...

These perisinusoidal cells orchestrate an array of changes including degradation of the normal ECM of liver, deposition of scar molecules, vascular and organ contraction, and release of cytokines.

On binding to ECM molecules, integrins are thought to undergo a conformational change, which allows the intracellular domain of their β-subunit to interact with focal-adhesion proteins ...

Unlike normal cells, cancer cells do not have repair ... of ultrasound-mediated cancer cell killing and the effect of the ECM binding spacing on it," explains S Manasa Veena, Ph.D. student in ...