Polymorphism in the drug-metabolizing enzymes was detailed over twenty years ago in the elegant work of Robert L. Smith 3. Tremendous scientific advances in our understanding of these enzymes ...

When children need medications, getting the dosing and method of administration right is like trying to hit a moving target with an untried weapon. Amid cuts to federal funding, US universities ...

Dr. Yee's lab was also part of a large pharmacogenomics investigation of drug metabolizing enzymes. Using a combination of experimental and computational methods, her group compared wild-type and ...

In addition, microsomes are pooled from multiple donors, which minimize the effect of variability between individuals. These subcellular fractions are a rich source of many drug-metabolizing enzymes ...

Unlike Paxlovid, Jun13296 shows no inhibition of major drug-metabolizing CYP450 enzymes in laboratory tests, suggesting it would not interfere with other medications and does not need to co-administer ...