we delve into the intricate mechanisms employed by intestinal cells to secure the vital nutrients and metabolic resources essential for preserving intestinal stem cell fate and function. And, how ...

Here we also discuss recent results from Drosophila showing that defects in cell polarity or asymmetric division of neural stem cells result in the development of brain tumours. Although it is not ...

It is unclear which intestinal epithelial cell-derived cytokines can precisely regulate intestinal stem cell (ISC) commitment toward specific mature cells. Here, authors identify an epithelial ...

On the left: Model organism fruit fly (Drosophila melanogaster), gastrointestinal tract highlighted in green. On the right: Microscope images of the fruit fly intestine where cell nuclei are ...

His research aims to identify the role of extracellular vesicles from intestinal epithelial cells ... following allogeneic stem cell transplantation. Understanding how IEC-EVs influence immune ...

During Drosophila development, LECs slowly begin to undergo apoptosis. In the late phase, the LECs are rapidly eliminated, with full replacement by the histoblasts.

“The cells dedifferentiate back into a type of regenerative stem cell after injury, and those stem cells eventually recover the intestine and turn back to normal cells.” Scientists have been looking ...

"The cells dedifferentiate back into a type of regenerative stem cell after injury ... H3K36 methylation regulates cell plasticity and regeneration in the intestinal epithelium, Nature Cell ...

As we age, the capacity of stem cells declines. Our laboratory studies both stem cell-intrinsic and extrinsic mechanisms altering tissue renewal capacity, and how such mechanisms ultimately result in ...

Mammalian intestinal epithelium is one of the most swiftly self-renewing tissues in the body, turning over completely every 3 to 5 days. Because of the absence of reliable stem cell markers, however, ...

Jennifer Stanford and Dr. Daniel Marenda. Her research focuses on both STEM education and understanding epigenetic regulation using Drosophila melanogaster as a model system. Her epigenetic regulation ...