More recently, we have developed and validated a strategy that leverages Drosophila genetics to enhance the power of human genetic studies (Shulman et al. 2011). Despite the promise of genome-wide ...

In humans, dosage compensation occurs through transcriptional inactivation of one X chromosome per cell. But in Drosophila, the male X chromosome is hyper-transcribed approximately two-fold.

Many insights gained from researching with Drosophila therefore provide important indications of how a process might unfold in mammals or humans. Analyzing the genome of a fly is easier than of a ...

Bachtrog earned an undergraduate degree in biology, and made use of her quantitative skill set to pursue a master’s thesis in population genetics. She wrote a computer program to identify ...

Heterochromatin is defined as the darkly-staining, densely-compacted part of chromosomes, generally found near centromeres and telomeres. One defining characteristic of heterochromatin is its high ...

"Vishva knew I was an expert in Drosophila (fruit fly) genetics, a resource that was not available at Genentech," Wolf said.