Instead, both OPC-14597 and OPC-4392 exhibit clear antagonist actions ... as well as at novel serotonin receptor subtypes (5-HT 6 and 5-HT 7). Antagonism of dopamine-mediated inhibition of cAMP ...

Adenosine A1 and A2A receptors are uniquely positioned to counteract the excessive stimulation of dopamine receptors produced by drugs of abuse. Thus, adenosine receptor stimulation provides a “brake” ...

It also develops AXS-05 (dextromethorphan-bupropion), an investigational N-methyl-D-aspartate receptor antagonist ... reuptake inhibitor and cortical dopamine modulator, which has completed ...