Third, we are analyzing the mechanisms by which adenosine and dopamine receptors interact to influence psychostimulant-induced behaviors. Adenosine also plays important roles in regulating neuronal ...

People with cannabis use disorder show signs of altered dopamine activity in the brain that mirror patterns seen in psychosis ...

This pathway senses inflammation and actively suppresses dopamine—a key driver of motivation—resulting in apathy and loss of drive. Blocking the pathway restored motivation, even though the ...

A region in the brain involved in the reward circuit. It processes dopamine signals and plays a key role in reinforcement and motivation. To determine if the pathway could be interrupted, the team ...