Orphan Drug Designation follows positive Phase 1 data presented at the 12th International Workshop on Waldenström Macroglobulinemia. First-in-class Bruton’s tyrosine kinase (BT ...

Right open reading frame kinase 2 (RIOK2) plays an essential role in ribosome assembly and cell growth, survival and stress responses. Research has linked RIOK2 to tumor progression and poor prognosis ...

Two papers in Nature now reveal that a glue degrader and cancer mutations enable an E3 ligase to recognize the same target protein through a convergent binding mode, which could inform discovery ...

Merck Sharp & Dohme LLC patents report the development of proteolysis targeting chimera (PROTAC) compounds comprising an E3 ubiquitin ligase (Von Hippel-Lindau disease tumor suppressor [VHL] ligands) ...

a selective Gd-IgA1 degrader being developed for IgA nephropathy, and BHV-1600, a β1AR autoantibody degrader for cardiomyopathy. Additional details and data regarding these TRAP degraders will be ...