During DNA replication, the unwinding of strands leaves a single strand vulnerable. How does the cell protect these strands from damage? How would you identify the protein that serves as a ...

the DNA replication checkpoint is the master surveillance system that steps in when a cell has problems during DNA replication. What does the DNA replication checkpoint really monitor? This ...

DNA is susceptible to damage caused by errors committed during replication and by environmental factors, such as radiation, oxidants, or alkylating agents. Repair reactions involve the excision of ...

A study links the loss of DNA methylation across the genome—as is common in cancer—to the disruption of the 3-D compartments that organize the genome and to the timing of DNA replication. Cell lines ...

This process is essential for the proper functioning and survival of all living organisms. DNA replication is the process by which the DNA molecule makes an exact copy of itself during cell division.

Scientists at the Wellcome Sanger Institute uncovered DNA damage that can persist for years, evading repair mechanisms and ...

Using lasers, they applied different amounts of force to mimic the tension DNA normally experiences during replication or proofreading to experimentally promote these enzymatic functions. Then, by ...

Accurate transmission of the genetic information requires complete duplication of the chromosomal DNA each cell division cycle. However, the idea that replication forks would form at origins of DNA ...

Structural maintenance of chromosomes (SMC) proteins are essential for successful chromosome transmission during replication and ... machines that shape our DNA can switch directions.

The study explores DNA damage and repair in neurons, which lack replication checkpoints due to their non-dividing nature. It reveals that DNA damage itself acts as a checkpoint, limiting genomic ...

Thymine dimers are a common type of UV-induced DNA lesion and are associated with skin cancer risk. During DNA replication, the complementary base pairing of thymine with adenine ensures the accurate ...

early during infection. Early expression of TAg was thought to push kidney cells to replicate the cell's DNA. This was supposed to give the virus access to the replication machinery it needed.