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Nature Methods | 当细胞开始“自白”:解码癌症基因的双面叙事
引言在肿瘤的微观宇宙中,每个癌细胞都像是携带双重身份的特工:它的DNA中潜藏着驱动恶性行为的突变密码,而RNA则实时演绎着这些指令带来的致命行动。然而,研究人员长久以来被迫以“分屏视角”观察这场阴谋——单细胞RNA测序(scRNA-seq)揭示细胞的行为特征,单细胞DNA测序(scDNA-seq)捕捉基因组的异常,但二者如同断线 ...
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