During DNA replication, the unwinding of strands leaves a single strand vulnerable. How does the cell protect these strands from damage? How would you identify the protein that serves as a ...

long stretches of the virus' genetic material into its outer shell during the process of viral replication. Details appear in the Dec. 7 issue of the scientific journal Nature. "This study provides ...

This study reveals how SV40 helicase unwinds DNA, highlighting ATP hydrolysis's role in translocation and offering insights into viral replication mechanisms.

ATP-dependent DNA ligases are also encoded by eukaryotic DNA viruses that conduct some or all of their replication cycle in the cytoplasm. These include vaccinia virus, African swine fever virus, and ...

Using cryo-electron microscopy and deep learning to observe the helicase Simian Virus 40 Large Tumor Antigen ... yet of the very first steps of DNA replication: 15 atomic states that describe ...

While scientists have long known the importance of helicase in DNA replication, "they did not know how DNA, helicases and ATP work together in a coordinated cycle to drive DNA unwinding," De ...

Using cryo-electron microscopy and deep learning to observe the helicase Simian Virus 40 Large Tumor Antigen ... yet of the very first steps of DNA replication: 15 atomic states that describe ...

Janet Mertz’s work with simian virus 40 DNA during her graduate years was pivotal for developing DNA recombination as we now know it. In September 1970, Janet Mertz joined the biochemistry department ...