In addition to exporting materials out of the nucleus, the protein, called Exportin-1 (also called Xpo1 or Crm1), seems to play a role in promoting gene transcription, the process that creates RNA ...

A new method for mapping torsion provides insights into the ways that the genome responds to the torsion generated by RNA polymerase II.

针对DNA损伤的反馈网络是一个特别有趣的系统，它与癌症的形成有关。当细胞的DNA受损时，修复系统就会启动。但修复系统无法保证工作结果的正确，它们可能会出错，而这些错误将导致威胁整个生物体的癌变。为了避免这种危险，让生物体健康存活下去，受到潜在危险突变 ...

This Analysis covers the ribbon–helix–helix (RHH) transcription-factor superfamily of proteins and focuses on the wealth of new structural information that has become available in the past year.

For the first time scientists have identified promising drug candidates that bind irreversibly with a notoriously "undruggable" cancer protein target, permanently blocking it.

Ultraviolet (UV) radiation is known to cause DNA damage, and while that damage may accumulate and eventually lead to diseases ...

Ultraviolet (UV) radiation from the sun is a well-known cause of DNA damage, which can lead to diseases like skin cancer. But ...

ELF4, a transcription factor belonging to the ETS family, has emerged as a pivotal regulator in cell differentiation, immune system function, and cancer progression. This newly published review ...

A single molecular switch is essential for blood stem cells to enter an activated, regenerative state in which they produce ...

Scientists have identified promising drug candidates that bind irreversibly with a notoriously “undruggable” cancer protein ...

Chronic hepatitis B virus (HBV) infection continues to pose a major global health threat. The virus evades immune responses and antiviral therapies due to the persistence of covalently closed circular ...