RNA polymerases are sloppy. A retrovirus with an RNA genome, which is copied into DNA by a reverse transcriptase, is prone to mutations because the enzyme lacks the 3’ to 5’ proofreading capability of ...

and each one needs to be read individually hundreds of times to capture the entire DNA sequence. Enlisting the help of some friends who had experience reverse engineering silicon, and armed with ...

Early steps of infection by HIV-1 involve entry of the viral core into cells, reverse transcription to form the linear viral DNA, and integration of that DNA into a chromosome of the host.

After removing the nucleos(t)ide analog reverse-transcriptase inhibitor monophosphate, the mode of DNA polymerization becomes active again (bottom). The P site and N site of HIV-1 reverse ...

Clin Drug Invest. 2007;27(8):509-531. Lamivudine, with its excellent record of efficacy, safety and tolerability in HIV-infected children, is a core component of the dual NRTI backbone of ...

These drugs work by inhibiting the viral reverse transcriptase enzyme, preventing the replication of the viral genetic material. Pyrimidine analogs, such as 5-fluorouracil (5-FU) and gemcitabine, are ...