DNA polymerase is responsible for the process of DNA replication, during which a double-stranded DNA molecule is copied into two identical DNA molecules. Scientists have taken advantage of the ...

One is that the DNA template somehow becomes defective during replication, and causes the polymerase to pause (Figures 3 and 4a). For example, a DNA base can be chemically modified or ...

Biology lectures teach students that when a cell’s replication machinery comes together, DNA polymerase takes off down the double-helix like a car on a highway ...

An analogous process occurs during chromosomal DNA replication, whereby the 5’-RNA segments that prime discontinuous synthesis of Okazaki fragments are excised, and the intervening gaps are filled in ...

The two DNA polymerases at the replication fork do not communicate at all. Their behavior is completely independent and stochastic. They each sample from the same distribution of possible ...

the helix structure is unwound special molecules break the weak hydrogen bonds between bases, which are holding the two strands together this process occurs at several locations on a DNA molecule ...

DNA replication is the process by which the DNA molecule makes an exact copy of itself during cell division. The double helix unwinds, and each strand serves as a template for the synthesis of a new ...

A study links the loss of DNA methylation across the genome—as is common in cancer—to the disruption of the 3-D compartments that organize the genome and to the timing of DNA replication. Cell lines ...

During DNA replication, the complementary base pairing of thymine with adenine ensures the accurate copying of genetic information. DNA polymerase enzymes use the existing DNA strand as a template and ...

More information: Marketa Tomkova et al, Human DNA polymerase ε is a source of C>T mutations at CpG dinucleotides, Nature Genetics (2024). DOI: 10.1038/s41588-024-01945-x Provided by Ludwig ...

Acyclovir gets converted to acyclovir triphosphate, which then inhibits replication of herpes viral DNA by competitively inhibiting viral DNA polymerase, incorporating into and terminating the ...