As previously mentioned, DNA methylation occurs at CpG sites, and a majority of CpG cytosines are methylated in mammals. However, there are stretches of DNA near promoter regions that have higher ...

The immunomodulatory character of bacterial CpG DNA is well known ... Remarkably, a single nucleotide change or methylation of the cytosine within the CpG motif was sufficient to completely ...

Epigenetic clocks that quantify rates of aging from DNA methylation patterns across the genome have emerged as a potential biomarker for risk of age-related diseases, like Alzheimer’s disease (AD), ...

Thanks to these advancements, measuring DNA methylation at all CpG sites in the human genome is now possible. Since the technology can read lengthy DNA sequences, it is also possible to measure ...

This method reduces the cost and complexity of methylome analysis. With RRBS, scientists enrich for GC-rich parts of the genome by digesting the DNA with an enzyme that generates fragments with CpG ...

Dunn, recently carried out a study exploring how DNA methylation, an epigenetic modification that entails the addition of a methyl group to the DNA, contributes to the well-documented relationship ...

A new study has uncovered a direct link between somatic mutations and epigenetic modifications, challenging established views ...

Despite progress in aging research, many epigenetic aging clocks still rely on simple linear models using CpG DNA methylation ...

The methylation of plasma cell-free DNA (cfDNA) has emerged as a valuable diagnostic and prognostic biomarker in various cancers including colorectal cancer (CRC). Currently, there are no biomarkers ...

DNA methylation is a key epigenetic mechanism ... measure methylation at androgen-sensitive cytosine-phosphate-guanine (CpG) sites, specifically targeting the methylation site cg21524116.

New research suggests that firstborn twins may have a greater risk of developing leukemia than second-born twins.