The genetic connections between DNA repair pathways and human cancer predisposition have fueled interest in the proteins that recognize and repair specific sites of DNA damage. The repair enzymes are ...

"The DNA inside our cells is constantly experiencing damage, and DNA repair is happening ... make it possible to use drugs that block homologous recombination to force cancer cells treated with ...

The finding provides a new understanding of a new type of cell signaling that may lead to more effective treatments for cancer ... drugs that are used to treat patients and cause DNA damage.

Some chemotherapy drugs work to counteract these mutations by blocking the action of growth-signaling proteins. The breast cancer drug ... that normally senses DNA damage and acts as a ...

This discovery deepens the understanding of a new type of cell signaling that ... was shown that when DNA damage occurs due to UV exposure or treatment with chemotherapeutic drugs such as actinomycin ...

Many people don’t realize that our bodies have built-in safeguards against cancer development. One such defense is cellular senescence, a state where damaged ... repair DNA, and that we could ...

This extension builds on a 2024 agreement to define and discover biomarkers within the DNA damage response (DDR ... across the entire landscape of cancer drug targets, including DDR.

Their findings demonstrated that cytoplasmic DNA, not RNA, set off a chain of events. cGAMP functioned as an endogenous second messenger to activate downstream signaling events that trigger antiviral ...