This review summarizes current arguments for CN and how to best select patients for surgery ... that cytoreductive nephrectomy (CN) had a clear role in metastatic renal cell carcinoma.

The strongest evidence for a survival benefit following CN stems from the two randomized Phase III studies investigating nephrectomy followed by IFN-α versus IFN-α alone. A combined analysis of ...

Stage IV, T3bN0M1 clear cell renal cell carcinoma ... the question of the most appropriate type of surgery must be addressed. Open cytoreductive nephrectomy is the gold standard treatment ...