Cytoreductive nephrectomy (CN) of the primary tumor ... substantially from CN in the era of targeted therapy and the indication for surgery should be 'personalized'. To obtain benefit from CN ...

Cytoreductive nephrectomy was then offered to the patient, who opted to undergo this procedure via a laparoscopic approach. Figure 2: Imaging of the patient's kidney after administration of sunitinib.

Therefore, there is a rationale for deferred nephrectomy following targeted therapy, and investigation of pretreated primary tumor tissue at a molecular level. As with drug therapy, the decision ...