Grapefruit juice, a health food staple, can interact with statins, rheumatoid arthritis drugs and psoriasis treatments.

Oranges and lemons, limes and grapefruit contain about 50 mg per ... Various isoforms of the enzyme cytochrome P450 are responsible for the oxidative metabolism of many drugs 15.

One key enzyme is cytochrome P450 3A4, or CYP3A4. As the furanocoumarins in grapefruit are broken down in the body, their resulting derivatives can block the action of CYP3A4. Thus, instead of ...

To break down some prescription drugs in the body, the liver uses enzymes called cytochrome P450. But grapefruit juice contains chemical compounds called furanocoumarins which can block the action ...