Most drugs are metabolized by CYP3A enzymes, and variations in expression ... Of particular importance are cytochrome P450 enzymes, heme-containing mono-oxygenases which catalyze the final step ...

The liver cytochrome P450 (CYP) enzymes play a crucial role in ... leading to a reduction in CYP3A activity in male mice, but not in females[1]. This finding highlights the sex-dependent ...