Cytochrome P450 enzymes (CYPs) are a large family of enzymes that play a crucial role in the metabolism of various substances, including drugs and xenobiotics (foreign compounds). In cancer ...

The original data comes from Zaretzki's dataset and is stored in the ./datasets/merged.sdf file. The training and testing data is in the same folder. The processing of atom-types, atom-based, and ...

There is evidence that enhanced metabolism often involves multiple genes from different herbicide detoxifying-enzyme families, such as cytochrome P450 monooxygenases (P450s), glutathione ...

CYPminer was developed in the Python language to facilitate rapid, comprehensive analysis of CYPs from genomes of all kingdoms. CYPminer consists of two procedures i) to generate the Genome-CYP Matrix ...

Grapefruit juice, a health food staple, can interact with statins, rheumatoid arthritis drugs and psoriasis treatments.

FIGURE 2. P450-active cycle exemplified for GPA crosslinking together with the heme oxygenase degradation pathway. PCP-X construct. The PCP-X construct from the kistamicin NRPS was expressed and ...

Microbial factories provide a sustainable alternative to tree sap for producing elusive plant molecules, offering new ...

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State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China University of Chinese Academy of Sciences, Beijing 100049, China State Key ...