P-glycoprotein (Pgp) transport was tested in ... (mean ratio 90% CI 6.04, 9.28). CONCLUSIONS: Cytochrome P450 3A4 is a primary enzyme responsible for the metabolic clearance of quetiapine.

The diagrams show what happens when P waves and S waves pass through the Earth. S waves do not pass through the Earth's core S waves cannot pass through the liquid outer core, but P waves can.