Figure 1 (reproduced from the original article by Mesecar and Koshland) shows the very small conformational changes in protein structure that cause differences in the catalytic constant of the ...

A novel protein cage system can control and visualize orientational changes in aromatic side chains upon ligand binding. By inducing coordinated molecular changes, this approach enables precise ...

Conformational changes in proteins, which occur at the nanoscale, are fundamental to processes ranging from enzyme catalysis ...

More information: Yao Hu et al, Exploring Protein Conformational Changes Using a Large‐Scale Biophysical Sampling Augmented Deep Learning Strategy, Advanced Science (2024). DOI: 10.1002/advs ...

This study provides compelling evidence that kinesin's stepping mechanism is governed by strain-induced conformational changes in its nucleotide-binding pockets. Using pre-steady state kinetics and ...

ProMIS Neurosciences (PMN) announced plans to deliver virtual oral presentations at the 2025 Alzheimer’s and Parkison’s Disease International ...