New research describes the early steps of colorectal tumor formation and lays a foundation ... This was followed by the appearance of precancerous cells at the top and bottom of the crypt. Deleting ...

"Colorectal cancer is very ... Without those stem cells, the crypt cells can't regenerate. To survive, the structure can spawn either a replacement population of regenerative stem cells at ...

An adaptation of the Vogelstein adenoma:carcinoma sequence. The acquisition of a mutation (or 'hit') in a stem cell within a crypt results in dysplastic progeny and leads to the entire crypt ...

Consider the repeating unit that forms the building block of the colon — the crypt 3. Within each crypt is a large population of differentiated cells with little or no proliferative capacity ...

Typical appearance of a sessile serrated adenoma/polyp in the ascending colon. Arrows indicate the ... with serrations in the upper half of the crypt with a lack of cytologic dysplasia.

An IBEC-led study describes the development of an innovative method to control the formation of crypt-like structures ... in detail key processes such as cell regeneration or changes associated ...

In a mouse with a functioning stem cell niche, the large intestine consists of numerous villi and crypts. Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases ...