Germinal centers are high-speed evolution machines. Tiny clusters in the lymph nodes, germinal centers refine antibodies ...

because such variants are more likely to be clonal and less likely to be lost through evolution. • Not all tumours undergo WGD, potentially limiting the generalizability of our findings.

To optimise technologies for in depth analysis of clonal architectures and dynamics in cancer. To integrate cancer genomics, clonal evolution with ecosystem and therapeutic selective pressures. To ...

Efficiency, for one thing, is on the side of asexual organisms: Without the need for males, every clonal individual passes a full set of identical genes onto the next generation. In addition ...