本研究首次描述了非洲血统 CLL 患者的白血病遗传和转录组特征。与欧洲血统 CLL 相比，非洲血统 CLL 具有更高的基因组复杂性，BRCC3、NOTCH1、NXF1 和 NFKBIE 等基因的突变患病率增加，同时存在 NF - κB 信号转录富集和端粒侵蚀增加的现象。

在AMPLIFY临床试验中，研究人员纳入了包括27个国家的800多名从未治疗的CLL患者，并将给予化疗的疗法与新型全药片疗法进行比较研究；针对CLL的标准化疗策略加上免疫疗法利妥昔单抗（rituximab）需要患者进行长时间的注射，并可能会引起长期的免疫抑制和其它令人不愉快的副作用发生。研究者John ...

The long-term safety of ibrutinib was proven in patients with newly diagnosed or relapsed or refractory (R/R) chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL). Quality-of ...

Hope is crucial for those of us with chronic lymphocytic leukemia, or any cancer, helping us navigate the disease's ...

Chronic lymphocytic leukemia (CLL) is a B-cell malignancy, with disease progression ranging from slow and indolent to ...

Researchers observed an increase in both CXCR4 and CD5 levels as the cells progressed to later stages of the cell cycle, particularly in the S/G2/M phases.

An international study published in the New England Journal of Medicine provides hope for chronic lymphocytic leukemia (CLL) ...

Research found that ibrutinib reduces red blood cell aggregation in patients with chronic lymphocytic leukemia (CLL), while ...

would result in better progression-free survival than chemoimmunotherapy in patients with untreated chronic lymphocytic leukemia (CLL) is unknown. In this phase 3, open-label trial, we included ...

Venetoclax, a selective Bcl-2 inhibitor, has proven effective in chronic lymphocytic leukemia (CLL), but genetic mutations or ...

During a Case-Based Roundtable® event, Nakhle Saba, MD, and participants discussed the data supporting the 2 newer BTK ...

A Cownose stingray at the Flordia Aquarium is being recognized as a part of the nationwide World Cancer Day celebration on ...