Translocations generate novel chromosomes, but are often linked to disorders like infertility and cancer. How do these new chromosomes generate problems, and how are they detected? Translocations ...

The transfer between the long arms of chromosomes 9 and 22 is called a reciprocal translocation. In Figure 1, the arrows indicate the translocation breakpoints for each of the involved chromosomes.

Chromosomal translocations occur in leukemias, lymphomas, sarcomas and some epithelial tumors and some generate unique fusion proteins. These translocation products may provide tumor-specific ...

Previous diagnostic methods, including short-read sequencing, were unable to provide an answer. With PacBio’s innovative multiomic solutions, researchers identified a chromosome X;13 balanced ...

Researchers have found that a translocation mutation (when part of a chromosome attaches to a different one) may cause the oncogenes to multiply too quickly and lead to cancer. Multiple myeloma ...

With PacBio’s innovative multiomic solutions, researchers identified a chromosome X;13 balanced translocation disrupting four key genes—each through a unique molecular mechanism. "This study ...

In the most comprehensive global analysis of genetic diversity ever undertaken, an international team of scientists has found ...