Structural variation in the genome can directly or ... reference assembly should be that it encompasses the longest chromosomal sequences, including polymorphic regions that might be absent ...

Although HR provides vital repair mechanisms, it is also hazardous, as revealed by the many ways in which it can lead to chromosomal structural change, including copy number variation. HR repair ...

The Layer Lab studies they ways in which genetic variation affects human health by developing computational genomics tools to analyze population-scale datasets. They are particularly interested in ...