Statins lower plasma cholesterol by upregulating LDL receptor gene expression and are consequently relatively ineffective in homozygous familial hypercholesterolemia (HoFH). The standard treatment ...

Very aggressive management of LDL cholesterol, including with apheresis, is required to improve the prognosis. Patients with homozygous familial hypercholesterolemia show reduced or absent ...

But others are predisposed to high cholesterol from a young age, and it has little to do with their lifestyle. These people have a genetic condition called familial hypercholesterolemia ...

High "bad" cholesterol, or hypercholesterolemia, affects about 10% of adults in the United States and about 7% of youth, according to government statistics. Genetics are one major reason for high ...

Dear Doctors: Can you please do a column about familial hypercholesterolemia? It is my diagnosis, and I would like you to explain it. My LDL is over 500. It is my understanding that there are ...