The researchers examined CAR T cell-mediated cancer cell killing in a two-tumor mouse model. Their goal was to test whether synthetic cells could protect CD19+ tumors from CAR T cells, while leaving ...

She explains that while smoking likely acts as the initial carcinogenic event that causes cell mutations, those cells may then need a secondary inflammatory process to drive tumor formation.

Schematic representation depicts the mechanism by which the ENO2-derived oncometabolite PEP directly binds to HDAC1 and thereby promotes H3K18la, which promotes macrophage polarization and leads ...