复旦大学附属中山医院等多单位的研究人员 Linnan Li、Hao Cheng 等人在《Cell Death Discovery》期刊上发表了题为 “METTL3 regulates autophagy of hypoxia - induced cardiomyocytes by targeting ATG7” 的论文。该研究揭示了 METTL3 ...

The term 'autophagy' was chosen to distinguish the lysosomal degradation, or 'eating' (phagy), of part of the cell's self (auto) from the breakdown of extracellular material (heterophagy).

A recent study from Tata Institute of Fundamental Research, Mumbai, India has revealed new details about how our cells clean ...

Get Instant Summarized Text (Gist) Autophagy, particularly through the protein ATG5, plays a crucial role in maintaining brain health by regulating glucose metabolism in neurons. In Purkinje cells ...

Recycling takes place in our cells at all times: in a process called autophagy, cell components that are no longer needed are enclosed by membranes and broken down into their basic building blocks.

A recent study from Tata Institute of Fundamental Research, Mumbai, India has revealed new details about how our cells clean up and recycle waste ...

Genotoxic stressors, including oxidative stress, inflammation, and environmental factors are closely intertwined processes that significantly contribute to ...

The Overholtzer lab studies mechanisms of nutrient sensing and cellular responses to nutrient starvation, including the nutrient recycling pathway autophagy, scavenging pathways such as ...

stabilizer TH-301 in models of pancreatic ductal adenocarcinoma (PDAC). It was seen that treatment with TH-301 led to significant dose-, time- and cell type-dependent decreases in viability.

This study presents a valuable finding on the alterations in the autophagic-lysosomal pathway in a Huntington's disease model. The evidence supporting the claims of the authors is solid. However, the ...