We propose that memory B-cell IL-10 production evolved primarily to downregulate vigorous adaptive pathogen-specific immune responses (involving combined TLR, BCR and CD40 signalling) and would ...

T-cell receptors (TCRs) from T cells, antibodies from B cells, MyD88 from white blood cells called monocytes, and CD40 from dendritic and other cells. The TCR and antibody components served as an ...