This flow-cytometry CTL (FCC) assay is predicated on measurement of CTL-induced caspase activation in target cells through detection of the specific cleavage of fluorogenic caspase substrates.

Breast cancer is one of the leading causes of mortality among women worldwide. Tumor necrosis factor α-induced protein 3-interacting protein 1 (TNIP1) is a ubiquitin-binding protein that is widely ...

They discovered that tumor cells can produce a novel short form of IL-18 via caspase-3 cleavage, which is independent of the traditional mature IL-18 pathway. Unlike mature IL-18, this short form ...