Host cells activate cell death pathways in response to bacterial manipulation of innate immune signalling, but the molecular ...

Microorganism- and host-derived 'danger' signals stimulate formation of a multiprotein complex, termed the inflammasome, which leads to processing and activation of caspase 1. Active caspase 1 ...

Scientists use cell death, whether by apoptosis or necrosis, to evaluate the toxicity or effectiveness of substances of interest, including potential therapeutic agents. For example, researchers will ...

Researchers have shed new light on how tissues in the body are repaired following the damage and premature death of tissue ...

A recent study has unveiled the pivotal role of Ferroptosis Suppressor Protein 1 (FSP1) in intervertebral disc degeneration ...

This focus has evolved to include the investigation of non-apoptotic functions of proteins that have long been considered to have roles in apoptosis, the caspase family of proteases. Our research ...

Caspase activity in MCF-7 and T47D cells transfected ... leading to increased apoptosis in MCF-7 cells. Overall, our study highlights TNIP1 as a crucial marker and suggests its potential as ...