These secrete large amounts of the cartilage extracellular matrix, which contains collagen and proteoglycans. Cartilage has limited repair capacity once damaged.

“This will expand our understanding of skeletal biomechanics. Right now, people only think about the matrix,” Plikus said. “But in lipo-cartilage, biomechanics derive from the organelles inside of the ...

Osteoarthritis disproportionally affects postmenopausal women, and a biological mechanism for why this occurs has been largely unkown, hindering development of effective treatments. That is in part ...

Cartilage’s biomechanical properties – it is strong but flexible – are due to cells called chondrocytes secreting large amounts of collagen-rich extracellular matrix (ECM), which surrounds ...

Cartilage comprises two major components ... induced loss of estrogen and progesterone promotes extracellular matrix degradation and chondrocyte deterioration, while restoring these hormones ...

Cartilage comprises two major components ... induced loss of estrogen and progesterone promotes extracellular matrix degradation and chondrocyte deterioration, while restoring these hormones ...

Most cartilage relies on an external extracellular matrix for strength, but "lipocartilage," which is found in the ears, nose and throat of mammals, is uniquely packed with fat-filled cells called ...