Dr. Ma adds, "Our results show that BB1 prevented the TNF-α increase in intestinal tight junction permeability via a toll-like receptor (TLR)-2 signal transduction pathway inhibition of NF-kB p50 ...

since many drugs target the tumor necrosis factor (TNF) pathway in other inflammatory diseases. “This could focus interest on evaluating already approved drugs for use in MS, but we have to bear ...

Cite this: TNF Signaling Inhibition in the CNS: Implications for Normal Brain Function and Neurodegenerative Disease - Medscape - Oct 17, 2008.