另外除了数据库验证，研究者利用空间单细胞蛋白组平台COMET在肺腺癌和胰腺癌中也进行验证。20-plex抗体检测肺腺癌，17-plex抗体检测胰腺癌。结果与CosMx/MERSCOPE转录组结果一致，证实四种CAF亚型的跨技术可重复性，将转录组定义的亚型锚定到具体组织学结构中。

Interestingly, dasatinib treatment increased cell-surface expression of CXCR4, which is important for survival of B-lineage cells, but this did not promote survival. Combined treatment of cells ...

"This did indeed lead to a significant reduction in CD8 + T cell migration into atherosclerosis plaques," affirms Duchêne, ...

Importantly, the interaction between CXCR4 and its ligand SDF-1 is involved in various disease conditions, such as cancer cell metastasis, leukemia cell proliferation, rheumatoid arthritis and ...