Interestingly, dasatinib treatment increased cell-surface expression of CXCR4, which is important for survival of B-lineage cells, but this did not promote survival. Combined treatment of cells ...

Other targets for entry inhibitors include two co-receptors on the cell surface—CCR5 and CXCR4—which together with CD4 mediate virus binding and membrane fusion 3. As CCR5, but not CXCR4 ...

Importantly, the interaction between CXCR4 and its ligand SDF-1 is involved in various disease conditions, such as cancer cell metastasis, leukemia cell proliferation, rheumatoid arthritis and ...