Vaccines elicited CD8 + T cells in 8 of 16 recipients (responders ... Indeed, vaccine-generated T-cell activity was weaker in the two responders whose cancer later returned than in other responders.

Although effector activity and memory formation in CD8 + T cells are known to depend on mTORC1-mediated metabolic regulation, the molecular mechanisms involved are lesser known. Here authors ...

In addition, researchers found that targeting BFAR could not only revive the antitumor activity of aged CD8 + T cells, but also enhance the sensibility of PD-1 blockade-based immunotherapy.

Scientists explore how the immune and nervous systems constantly communicate, influencing brain diseases, behavior, and ...

In a new study published in Nature, led by scientists at the Allen Institute, La Jolla Institute for Immunology, and UC San Diego, researchers reveal how cells known as tissue-resident memory CD8 ...

Pathogen-fighting immune cells called tissue-resident memory CD8 T cells (TRM cells) go through a surprising transformation -- and relocation -- as they fight infections in the small intestine.

Type 1 diabetes raises important questions about immune cell activity that have broad implications for immunotherapy. Philip M and Schietinger A. CD8 T cell differentiation and dysfunction in cancer.

A new study has found a surprising link between high levels of methylmalonic acid and the weakening of CD8 + T cells, ...

Early data shows potent and selective CD8+ T cell activation without substantial changes to Treg and NK cell numbers and initial evidence of anti-tumor activity, including confirmed objective ...