In addition, researchers found that targeting BFAR could not only revive the antitumor activity of aged CD8 + T cells, but also enhance the sensibility of PD-1 blockade-based immunotherapy.

Although effector activity and memory formation in CD8 + T cells are known to depend on mTORC1-mediated metabolic regulation, the molecular mechanisms involved are lesser known. Here authors ...

Vaccines elicited CD8 + T cells in 8 of 16 recipients (responders ... Indeed, vaccine-generated T-cell activity was weaker in the two responders whose cancer later returned than in other responders.

Scientists explore how the immune and nervous systems constantly communicate, influencing brain diseases, behavior, and ...

In a new study published in Nature, led by scientists at the Allen Institute, La Jolla Institute for Immunology, and UC San Diego, researchers reveal how cells known as tissue-resident memory CD8 ...

Developing effective treatments and understanding how the mechanism of the immune system have always been challenging for ...

Pathogen-fighting immune cells called tissue-resident memory CD8 T cells (TRM cells) go through a surprising transformation -- and relocation -- as they fight infections in the small intestine.

A new study has found a surprising link between high levels of methylmalonic acid and the weakening of CD8 + T cells, ...

Immune cells in the bone marrow microenvironment of AML patients are key in distinguishing a response to immunotherapy.

Within the immune system, interleukin-15 (IL-15) plays a relevant role by boosting the number of cytotoxic T cells and NK cells, the major drivers of anticancer immune response. Researchers from Sotio ...

Type 1 diabetes raises important questions about immune cell activity that have broad implications for immunotherapy. Philip M and Schietinger A. CD8 T cell differentiation and dysfunction in cancer.

Early data shows potent and selective CD8+ T cell activation without substantial changes to Treg and NK cell numbers and initial evidence of anti-tumor activity, including confirmed objective ...