Although effector activity and memory formation in CD8 + T cells are known to depend on mTORC1-mediated metabolic regulation, the molecular mechanisms involved are lesser known. Here authors ...

In addition, researchers found that targeting BFAR could not only revive the antitumor activity of aged CD8 + T cells, but also enhance the sensibility of PD-1 blockade-based immunotherapy.

Scientists explore how the immune and nervous systems constantly communicate, influencing brain diseases, behavior, and ...

In a new study published in Nature, led by scientists at the Allen Institute, La Jolla Institute for Immunology, and UC San Diego, researchers reveal how cells known as tissue-resident memory CD8 ...

Pathogen-fighting immune cells called tissue-resident memory CD8 T cells (TRM cells) go through a surprising transformation -- and relocation -- as they fight infections in the small intestine.

In a new study published in Nature, led by scientists at the Allen Institute, La Jolla Institute for Immunology, and UC San Diego, researchers reveal how cells known as tissue-resident memory CD8 ...

Type 1 diabetes raises important questions about immune cell activity that have broad implications for immunotherapy. Philip M and Schietinger A. CD8 T cell differentiation and dysfunction in cancer.

A new study has found a surprising link between high levels of methylmalonic acid and the weakening of CD8 + T cells, ...