Foxp3 may steer T cells down specific pathways by amplifying and stabilizing features advantageous to Treg differentiation, such as CD25 and CTLA-4 expression, or by repressing features ...

Engineered suppressor cells that produced suppressive cytokines including interleukin-10, programmed death ligand 1, and transforming growth factor–β1 (TGFβ1), along with inflammatory cytokine sinks ...

The scientists tailored a batch of immune referees to search for human pancreatic islet cells and then produce TGF-Beta and CD25, molecules that can muzzle killer T cells. They introduced the ...