We were the first in Europe to develop chemotherapeutic agents, and we discovered, and with The Royal Marsden NHS Foundation Trust developed, the chemotherapy drugs busulfan, chlorambucil, melphalan ...

Either hydroxyurea or busulfan as single agents can provide hematologic control in the majority of patients (> 75%) with chronic phase CML. [32] These hematologic "remissions" are characterized by ...

Treosulfan (Grafapex) was approved in Canada in June 2021 for the same use and is marketed under the brand name Trecondyv.