Artificial biosynthetic pathways are typically assembled and optimized progressively, from earlier to later steps. This commentary highlights the potential of an alternate regressive method for ...

Protein trafficking and the dynamics of the secretory pathway are crucial processes in cellular function, involving the transport of proteins and lipids to their designated locations within the cell.

we suggest that this approach will facilitate large-scale screening of small molecules that specifically block the biosynthesis of harmful secretory pathway proteins," says Kadokura. Notably ...