Artificial biosynthetic ... directed evolution, for instance) would be mediated via an assay dependent on formation of product or consumption of the terminal intermediate. Next, the gene encoding ...

Biosynthesis of secondary metabolites is complex, involving multiple enzymes and assembly lines, known to be encoded within large biosynthetic gene clusters (BGCs). In fact, there are actually ...

For instance, orphan gene clusters that correspond to biosynthetic loci for which the metabolite is not known are commonly found in the genomes of microorganisms. “It is hard to estimate [how ...

TaxiBGC (Taxonomy-guided Identification of Biosynthetic Gene Clusters) is a computational pipeline for predicting experimentally characterized Biosynthetic Gene Clusters (BGCs) and their known ...

See the accompanying LISCENSE file for terms of this license. ClustCompare comprises several piplines designed to compare secondary metabolite biosynthetic gene clusters (BGCs) to each other based on ...

Since biosynthetic gene clusters are often less active under laboratory conditions, they are extracted from the genome using ACTIMOT and inserted into a mobile genetic unit that is then multiplied ...

2021. Vertical inheritance facilitates interspecies diversification in biosynthetic gene clusters and specialized metabolites. mBio. DOI: 10.1128/mBio.02700-21 AB Chase, C Weihe, JBH Martiny. 2021.