The cholesterol 7α-hydroxylase enzyme (encoded by CYP7A1) represents the rate-limiting step of the multi-enzymatic bile-acid biosynthetic pathway. Bile acids play a crucial role in dietary lipid ...

Pregnancy. Nursing mothers. Reduced absorption with bile acid sequestrants (eg, cholestyramine, colestipol), and aluminum-containing antacids. Estrogens, oral contraceptives, clofibrate ...