In 1981, the first azole antifungal, the diazole ketoconazole, was introduced to the market; then, in the early 1990s the first-generation triazoles, fluconazole and itraconazole, became available.

Fluconazole, a very safe and effective azole antifungal, requires a much higher dose in children (12 mg/kg/day) compared with adult patients. In addition, the neonatal field is exploring ...

As with antibiotics, controlling the use of fungicides in agriculture is seen as key to fending off the rising threat of antimicrobial resistance - iStockphoto ...

More information: Elevated mutation rates in multi-azole resistant Aspergillus fumigatus drive rapid evolution of antifungal ...

“This means that isolates that are already resistant to our first line treatments could develop resistance to new drugs 5 times faster than drug resistant isolates, potentially leading to strains that ...

Since mid-2002, two new antifungal drugs — voriconazole, a third-generation azole, and caspofungin, a member of a new class of drugs called echinocandins — have been marketed in Spain.