Although the Cvt pathway is the only known biosynthetic use of autophagy, selectivity represents an important aspect of many autophagic processes. For example, specific organelle degradation has ...

Organismal lifespan can be extended by genetic manipulation of cellular processes such as histone acetylation, the insulin/IGF-1 (insulin-like growth factor 1) pathway or the p53 system.

The Overholtzer lab studies mechanisms of nutrient sensing and cellular responses to nutrient starvation, including the nutrient recycling pathway autophagy, scavenging pathways such as ...

The process by which cells eliminate waste and recycle valuable materials, known as autophagy, is vital for health. In conditions such as Parkinson’s and Alzheimer’s disease, the accumulation ...

This research focuses on how the mTOR pathway influences key renal cells ... of mTOR contributes to kidney injury by inhibiting autophagy, increasing oxidative stress, and promoting inflammation.